PrairiEDocs e-newsletter #29
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Surveying the
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for the emergency medicine practitioner
Issue #29 "fasten your seat belt and adjust
your headrest as this
electronic ed-venture continues" February 2, 2002
In this issue:
Adding
B-12 to Heart Disease Prevention Strategies?
Motorcycle
Fatalities Increase 17% from 1997 to 1999
Defibrillator
Debate--Sell Without Prescription?
Broselow
Tape Accuracy Reviewed
Cancer
Vaccine?
Are
Infections Risk Factors for Strokes?
Your
Warning Light is On!
Chillingly
Effective
How
Prudent is a Prudent Layperson?
Possible
Cure for Diabetes Begins Safety Trials
Audio
Cassette Tape on Bioterrorism
Factoid
Cool Web Sites
Quotable Quotes
ERDOCS
listserv
How
to get in touch with us; questions; sponsorship
Adding
B-12 to Heart Disease Prevention Strategies?
While
research continues to implicate folic acid in the prevention of
heart disease, a new study suggests that adding B-12 may strengthen
the protection even further.
Folic acid reduces the levels of homocysteine, and research published
in the January 19 issue of Lancet suggests that B-12 helps keep
these levels reduced. Homocysteine has been identified as a potentially
harmful amino acid, that has been measured in elevated levels
in patients with heart disease.
The study study looked at 30 men and 23 women who took folic acid
supplements for 26 weeks. Men took increasing doses, from 100
to 400 micrograms; women took 500 micrograms.
Homocysteine levels decreased while the subjects were taking the
folic acid. Once folate levels were increased, however, increases
in vitamin B-12 levels were necessary to keep homocysteine at
low levels.
Motorcycle
Fatalities Increase 17% from 1997 to 1999
Two National
Highway Traffic Safety Administration (NHTSA) studies cite dramatic
increases in motorcycle-related fatalities, with the single biggest
increase found in the over 40 age group and with motorcycles with
bigger than 1,000 cc engines. Additionally, the report in the
February issue of Annals of Emergency Medicine noted that while
these riders were less likely to speed and more likely to wear
a helmet, they also consumed more alcohol than any other age group
except the 30-39 year-old group. Further investigation is called
for in identifying effective strategies in reducing this trend.
Defibrillator
Debate--Sell Without Prescription?
The National
Press Club sponsored debate at the end of January, focusing on
whether a prescription should remain necessary for the members
of the public interested in acquiring an AED.With planners hoping
that defibrillators someday be as common as fire extinguishers,
and others predicting they could save 75 percent of all sudden
cardiac arrest victims, debate proved lively as to whether the
federal law requiring a prescription be overturned. Lance Becker,
the director of the Emergency Resuscitation Research Center at
the University of Chicago, stated the survival rate for sudden
cardiac arrest is 2 percent, and it jumps to 50 percent when a
defibrillator is available in a public area, and it may jump to
75 percent if AEDs are in homes.'' One of the panelists, Gust
Bardy, a cardiologist at the University of Washington Medical
Center, discussed a project he recently conducted with a group
of sixth graders. Bardy gave the children brief instructions on
how to use a defibrillator on a mannequin. ``They performed it
correctly,'' he said. ``It took them 90 seconds and it takes paramedics
an average of 60 seconds.''
Broselow
Tape Accuracy Reviewed
A recent study
in the British Journal of Anesthesia looked at the Broselow tape
that has become a standard in pediatric resuscitation in the U.S.
The tape uses body length to help estimate body weight and endotracheal
tube size. Researchers used pediatric anesthesia records at a
city hospital in 1999 as a basis for their review.
Researchers
found a good correlation was found between the Broselow estimated
weight and the actual measured weight. The Broselow weight was
within 10% error of the measured weight in 65% of children. Researchers
concluded that it was more accurate with younger children. Tracheal
tube selection by the Broselow tape method was adequate in 55%
but underestimated the actual tube size in 39%. An alternate technique,
using an age-based formula, matched the actual tracheal tube size
in 41% of children but overestimated it in 57%. http://bja.oupjournals.org/cgi/content/abstract/88/2/283
Cancer
Vaccine?
Melanoma is
expected to strike 51,400 Americans this year and kill 7,800.
While melanoma accounts for only about 4 percent of all skin cancer
cases, it causes almost 80 percent of skin cancer deaths. So it
is with great anticipation that scientists are looking at a possible
breakthrough cancer vaccine, courtesy the results from Dr. Donald
Morton at the John Wayne Cancer Institute in Santa Monica, Calif.,
reports that preliminary results from tissue samples and records
of 30,000 patients prove that there is a doubling of survival
when using the latest of his four attempts at a vaccine.
The American
Cancer Society reminds us all that the following are the ABCD
warning signs in evaluating moles or other spots on the skin that
are changing in size, shape, or color. The warning signs of melanoma
are often called the ABCD's:
A - asymmetry.
One half of a mole or pigmented spot doesn't match the other half;
B - border irregularity. The edges are notched, ragged or blurred;
C - color. It varies from one part of the mole or spot to another.
There may be shades of tan, brown, black and sometimes white,
red or blue;
D - diameter greater than that of a pencil eraser. Melanomas can
develop from or near an existing mole, or away from such blemishes.
They appear most often on the upper backs of men or women or the
legs of women, but they can occur anywhere on the body.
The main preventable
cause of melanoma is excessive sun exposure. So doctors advise
avoiding or limiting sun exposure from 10 a.m. to 4 p.m., and
using protective clothing and sunscreen with an SPF rating of
at least 15. Severe sunburns in childhood may particularly increase
the risk of melanoma in later life, so children in particular
should be protected, doctors say.
Are
Infections Risk Factors for Strokes?
Influenza
vaccination and lowered stroke risk----French researchers speculate
on whether it's a case of correlation or causation--in their report
in the February's Stroke: Journal of the American Heart Association.
They collected
data on 90 consecutive patients hospitalized for strokes that
were also 60 years of age and older, comparing them with 180 population-based
controls. They found there were significantly fewer subjects who
had a recent influenza vaccination among those who had a stroke
than among controls (46.7% versus 59.4%, p = 0.036. This effect
was particularly strong among those under 75 years of age. Adjustments
were made for age, other risk factors for stroke and recent antibiotic
use, stroke risk was reduced among patients who had been vaccinated
in the year of the study (odds ratio0.50, p = 0.033). Risk was
also reduced for those vaccinated during the preceding 5 years
(odds ratio 0.42, p =0.009) compared with those who had not been
vaccinated.
The French
researchers are now increasing their study to 1000 patients and
2000 controls and hoping to perform a randomized control trial
to confirm a protective effect of influenza vaccination against
stroke.
Stroke 2002;33
Your
Warning Light is On!
An interesting
new application for jet engine sensor technology is being investigated
for use in animals, with human testing slated to begin this spring.
The sensors
are smaller than a dime, no wires are involved, and powered by
a handheld transmitter/receiver. They are called micro-electro
mechanical systems (MEMS) and were developed by Mark Allen, PhD,
a professor of electrical engineering at the Georgia Institute
of Technology. The MEMS sensor is made from a flexible plastic
and is paper-thin. It can be attached to a catheter to monitor
pressure changes.
Projected
uses included blood pressure monitoring and pressure fluctuations
in the areas of vessel aneurisms.
Chillingly
Effective
Researchers
are investigating yet another weapon to discourage the restenosis
in angioplasty patients. A newer variation, called cryoplasty
uses pressurized nitrous oxide injected into the balloon catheters.
The nitrous
oxide expands as it turns into a gas, cooling surrounding tissue
dramatically. Researchers claim this procedure is gentler; than
conventional balloon angiography. The inventor, James Joye, DO,
recently reported on results from 15 patients. Twelve of the fifteen
were successfully opened up using only this procedure. None of
these 12 have had restenosis.
These results
exceed expectations with conventional balloon procedures. The
other three people in the study required additional treatment
initially. The cryoplasty test is scheduled for 70 more patients
early this year.
How
Prudent is a Prudent Layperson?
Since state
and federal several legislative initiatives in recent years have
been predicated on such terminology, a study was conducted to
identify what the "prudent layperson" was likely to
identify as "emergency medical conditions." After a
comprehensive tabulation of symptom classifications from the diagnostic
coding manual (the International Classification of Diseases, aka
as ICD-9), a survey of non-medical laypersons was then conducted.
Researchers
reported using analysis that included descriptive statistics,
proportional calculations, and 95% confidence intervals.
Only 25 out
of 87 signs and symptoms listed as such by the ICD-9 were considered
"emergency medical conditions" by more than half of
those surveyed who were self-defined as prudent laypersons. Most
often listed as emergencies by them were loss of consciousness,
seizure, no recognition of one side of the body, paralysis, shock,
gangrene, coughing blood, trouble breathing, chest pain, and choking.
Pain (except renal colic or chest pain) was not considered an
emergency; nor were signs and symptoms specifically related to
gynecologic disorders.
Researchers
concluded that "use of the prudent layperson standard for
reimbursable emergency health services may not reflect the actual
scope of symptoms necessitating emergency care."
Possible
Cure for Diabetes Begins Safety Trials
Having successfully
"cured" diabetes in lab animals, human trials have begun
with INGAP (neogenesis-associated protein) peptide---a chemical
messenger capable of triggering ransformation of pancreatic tissue
into islet cells.
The discovery
of INGAP began accidentally. Working to develop a laboratory model
of pancreas disease, Rosenberg and Vinik wrapped an animal pancreas
in cellophane. To their surprise, the isolated pancreas began
to grow new islet cells. Further research showed that this happened
because the pancreas was making INGAP. Later studies showed that
only a small portion of INGAP -- INGAP peptide -- was needed to
stimulate growth of new islet cells. Eventually, the researchers
discovered the INGAP gene and learned how to make large quantities
of the INGAP peptide.
Apparently, the pancreas has cells within itself with stem cell-like
properties; if given the right stimulus, they can transform into
beta or islet cells capable of manufacturing insulin. Even single
doses of INGAP peptide have cuased increased production of insulin
and a lowering of blood sugar.
The initial human study will test the safety of INGAP peptide.
Initially, 62 patients with type 1 or type 2 diabetes will receive
increasing doses at any of three medical centers: the University
of Texas Health Science Center in San Antonio; the University
of North Carolina in Chapel Hill; and the MedStar Research Institute
in Washington, D.C.
INGAP peptide
was invented by Lawrence Rosenberg, MD, PhD, of Canada's McGill
University and Aaron I. Vinik, MD, of East Virginia Medical School,
Norfolk, patented by the two universities and licensed to GMP
Companies Inc., Ft. Lauderdale, Fla. An earlier licensing agreement
with Eli Lilly and Company expired.
Islet cell
transplantation is another alternative being explored. Tissue
rejection does not seem to be a significant problem, but supply
of donor tissue may be. There is a major study underway focusing
on islet cell transplantation. Currently, it takes two donors
to provide enough islet cells for a single transplant. It is estimated
that 3,000 donor organs become available each year and there are
some 800,000 people with type 1 diabetes.
Audio
Cassette Tape on Bioterrorism
(from the
web site for American College of Physicians--American Society
of Internal Medicine):
The audio
recording of the Distinguished Lecture by Richard P. Wenzel, FACP
on Bioterrorism is now available. Recorded at the 2000 ACP-ASIM
Annual Session, the speaker, Dr. Wenzel, addresses the following
three clinical questions:
What are the
likely pathogens that bioweaponeers would use?
What are the likely manifestations of illness caused by these
pathogens?
What are the characteristics of a biological terror agent?
To order,
call toll-free 1-800 776-5454 and ask for audiotape #DL 56, Bioterrorism
or order online at http://www.cmeunlimited.org/acp/dl56
(associate member $12, member $13, nonmember $14)
Factoids
Eighty-two
percent of California hospital emergency rooms (ERs) lost money
in 2000, says a report recently issued by the California Medical
Association (CMA). CMA calculates that California ERs in
fiscal year 2000 collectively lost $325 million, up from $317
million in fiscal year 1999.
Cool Web Sites
National
Library of Medicine presents
http://www.sis.nlm.nih.gov/Tox/biologicalwarfare.htm
Biological
pathogens released intentionally or accidentally, or naturallyoccurring,
can result in disease or death. Recent terrorist attacks in theUnited
States and elsewhere have prompted widespread and justified societal
concerns about the hostile use of biological agents and their
potential threats to health.
Human exposure
to these agents may occur through inhalation, skin (cutaneous)
exposure, or ingestion of contaminated food or water. Following
exposure, physical symptoms may be delayed and sometimes confused
with naturally occurring illnesses. Biological warfare agents
may persist in the environment and cause problems some time after
their release. The selective list of agents below fall into four
major groups, three classes of microorganisms - bacteria, rickettsia,
and viruses, plus bacterial toxins, which are poisonous chemicals
produced by bacteria. Incubation period, duration of illness,
symptoms, means of transmission, treatment, and prognosis include
the following: Anthrax, Smallpox, Plague, Brucellosis, Botulism,
Tularemia Q Fever, and Viral Hemorrhagic Fevers
Malpractice
Reform
www.malpracticecrisis.com
Lists state
by state legislative efforts at tort reform, as well as
up-to-date information and a history of malpractice concerns and
reform.
Learn the
difference between Hepatitis A, B, C at:
http://www.immunize.org/catg.d/p4075abc.pdf
You can
see photos of vaccine-preventable diseases at:
http://www.immunize.org/catg.d/pict001.htm
A fun personality
test based on color sequence selection: http://www.colorgenics.com/intro.html
Quotable Quotes
J Norman
Mailer (1923-____) US novelist, journalist:
When considering
regulations, half of what is published is probably 50% incorrect.
The rest is 75% wrong.
Will Rogers
(1879 - 1935) US humorist, author:
Even if you're
on the right track, you'll get run over if you just sit there.
Robert Benchley
US author:
Drawing on
my fine command of the English language, I said nothing.
ERDOCS e-mail group (listserv)
As a Clinician providing
acute and emergency medical care, you are invited to visit and
participate in our new ERDOCS group at eGroups, a free, easy-to-use
email group service! You have plenty of experiences to share,
questions to ask, concerns and opinions to voice, suggestions,
news to post, tips to offer, etc. and can do so within this framework.
This is a versatile system for posting things to be sent to a
group to peruse, respond to, or simply be aware of. It eliminates
conventional mail delays and allows you to review and post at
your leisure. (We still have the more open-ended [any visitor
can observe/post] discussion group at the ACUTE CARE, INC. web site). Our goal is to give you a variety of
feedback and communication tools.
The manager/moderator for this ERDOCS egroup is the webmaster
for the ACUTE CARE, INC. website (http://www.acutecare.com/), Paul Hudson.
You can subscribe by sending an e-mail indicating your wish to
be included to Paul at mailto:paulh@acutecare.com
As this site grows, it will feature news, calendars, links to
references, resources, and other useful features. We hope you
will support this effort to foster ongoing communication amongst
EM providers.
This e-newsletter is available through the generous unrestricted
support of
ACUTE CARE, INC. You
can find out more about ACUTE CARE, INC.
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