PrairiEDocs e-newsletter #29

Other archived PrairiEDocs e-newsletters


Surveying the land (and web) for news (and more)
for the emergency medicine practitioner



Issue #29 "fasten your seat belt and adjust your headrest as this
electronic ed-venture continues" February 2, 2002



In this issue:

Adding B-12 to Heart Disease Prevention Strategies?

Motorcycle Fatalities Increase 17% from 1997 to 1999

Defibrillator Debate--Sell Without Prescription?

Broselow Tape Accuracy Reviewed

Cancer Vaccine?

Are Infections Risk Factors for Strokes?

Your Warning Light is On!

Chillingly Effective

How Prudent is a Prudent Layperson?

Possible Cure for Diabetes Begins Safety Trials

Audio Cassette Tape on Bioterrorism

Factoid

Cool Web Sites

Quotable Quotes

ERDOCS listserv

How to get in touch with us; questions; sponsorship


Adding B-12 to Heart Disease Prevention Strategies?

While research continues to implicate folic acid in the prevention of heart disease, a new study suggests that adding B-12 may strengthen the protection even further.


Folic acid reduces the levels of homocysteine, and research published in the January 19 issue of Lancet suggests that B-12 helps keep these levels reduced. Homocysteine has been identified as a potentially harmful amino acid, that has been measured in elevated levels in patients with heart disease.


The study study looked at 30 men and 23 women who took folic acid supplements for 26 weeks. Men took increasing doses, from 100 to 400 micrograms; women took 500 micrograms.
Homocysteine levels decreased while the subjects were taking the folic acid. Once folate levels were increased, however, increases in vitamin B-12 levels were necessary to keep homocysteine at low levels.


Motorcycle Fatalities Increase 17% from 1997 to 1999

Two National Highway Traffic Safety Administration (NHTSA) studies cite dramatic increases in motorcycle-related fatalities, with the single biggest increase found in the over 40 age group and with motorcycles with bigger than 1,000 cc engines. Additionally, the report in the February issue of Annals of Emergency Medicine noted that while these riders were less likely to speed and more likely to wear a helmet, they also consumed more alcohol than any other age group except the 30-39 year-old group. Further investigation is called for in identifying effective strategies in reducing this trend.


Defibrillator Debate--Sell Without Prescription?

The National Press Club sponsored debate at the end of January, focusing on whether a prescription should remain necessary for the members of the public interested in acquiring an AED.With planners hoping that defibrillators someday be as common as fire extinguishers, and others predicting they could save 75 percent of all sudden cardiac arrest victims, debate proved lively as to whether the federal law requiring a prescription be overturned. Lance Becker, the director of the Emergency Resuscitation Research Center at the University of Chicago, stated the survival rate for sudden cardiac arrest is 2 percent, and it jumps to 50 percent when a defibrillator is available in a public area, and it may jump to 75 percent if AEDs are in homes.'' One of the panelists, Gust Bardy, a cardiologist at the University of Washington Medical Center, discussed a project he recently conducted with a group of sixth graders. Bardy gave the children brief instructions on how to use a defibrillator on a mannequin. ``They performed it correctly,'' he said. ``It took them 90 seconds and it takes paramedics an average of 60 seconds.''


Broselow Tape Accuracy Reviewed

A recent study in the British Journal of Anesthesia looked at the Broselow tape that has become a standard in pediatric resuscitation in the U.S. The tape uses body length to help estimate body weight and endotracheal tube size. Researchers used pediatric anesthesia records at a city hospital in 1999 as a basis for their review.

Researchers found a good correlation was found between the Broselow estimated weight and the actual measured weight. The Broselow weight was within 10% error of the measured weight in 65% of children. Researchers concluded that it was more accurate with younger children. Tracheal tube selection by the Broselow tape method was adequate in 55% but underestimated the actual tube size in 39%. An alternate technique, using an age-based formula, matched the actual tracheal tube size in 41% of children but overestimated it in 57%. http://bja.oupjournals.org/cgi/content/abstract/88/2/283


Cancer Vaccine?

Melanoma is expected to strike 51,400 Americans this year and kill 7,800. While melanoma accounts for only about 4 percent of all skin cancer cases, it causes almost 80 percent of skin cancer deaths. So it is with great anticipation that scientists are looking at a possible breakthrough cancer vaccine, courtesy the results from Dr. Donald Morton at the John Wayne Cancer Institute in Santa Monica, Calif., reports that preliminary results from tissue samples and records of 30,000 patients prove that there is a doubling of survival when using the latest of his four attempts at a vaccine.

The American Cancer Society reminds us all that the following are the ABCD warning signs in evaluating moles or other spots on the skin that are changing in size, shape, or color. The warning signs of melanoma are often called the ABCD's:

A - asymmetry. One half of a mole or pigmented spot doesn't match the other half;
B - border irregularity. The edges are notched, ragged or blurred;
C - color. It varies from one part of the mole or spot to another. There may be shades of tan, brown, black and sometimes white, red or blue;
D - diameter greater than that of a pencil eraser. Melanomas can develop from or near an existing mole, or away from such blemishes. They appear most often on the upper backs of men or women or the legs of women, but they can occur anywhere on the body.

The main preventable cause of melanoma is excessive sun exposure. So doctors advise avoiding or limiting sun exposure from 10 a.m. to 4 p.m., and using protective clothing and sunscreen with an SPF rating of at least 15. Severe sunburns in childhood may particularly increase the risk of melanoma in later life, so children in particular should be protected, doctors say.


Are Infections Risk Factors for Strokes?

Influenza vaccination and lowered stroke risk----French researchers speculate on whether it's a case of correlation or causation--in their report in the February's Stroke: Journal of the American Heart Association.

They collected data on 90 consecutive patients hospitalized for strokes that were also 60 years of age and older, comparing them with 180 population-based controls. They found there were significantly fewer subjects who had a recent influenza vaccination among those who had a stroke than among controls (46.7% versus 59.4%, p = 0.036. This effect was particularly strong among those under 75 years of age. Adjustments were made for age, other risk factors for stroke and recent antibiotic use, stroke risk was reduced among patients who had been vaccinated in the year of the study (odds ratio0.50, p = 0.033). Risk was also reduced for those vaccinated during the preceding 5 years (odds ratio 0.42, p =0.009) compared with those who had not been vaccinated.

The French researchers are now increasing their study to 1000 patients and 2000 controls and hoping to perform a randomized control trial to confirm a protective effect of influenza vaccination against stroke.
Stroke 2002;33


Your Warning Light is On!

An interesting new application for jet engine sensor technology is being investigated for use in animals, with human testing slated to begin this spring.

The sensors are smaller than a dime, no wires are involved, and powered by a handheld transmitter/receiver. They are called micro-electro mechanical systems (MEMS) and were developed by Mark Allen, PhD, a professor of electrical engineering at the Georgia Institute of Technology. The MEMS sensor is made from a flexible plastic and is paper-thin. It can be attached to a catheter to monitor pressure changes.

Projected uses included blood pressure monitoring and pressure fluctuations in the areas of vessel aneurisms.


Chillingly Effective

Researchers are investigating yet another weapon to discourage the restenosis in angioplasty patients. A newer variation, called cryoplasty uses pressurized nitrous oxide injected into the balloon catheters.

The nitrous oxide expands as it turns into a gas, cooling surrounding tissue dramatically. Researchers claim this procedure is gentler; than conventional balloon angiography. The inventor, James Joye, DO, recently reported on results from 15 patients. Twelve of the fifteen were successfully opened up using only this procedure. None of these 12 have had restenosis.

These results exceed expectations with conventional balloon procedures. The other three people in the study required additional treatment initially. The cryoplasty test is scheduled for 70 more patients early this year.


How Prudent is a Prudent Layperson?

Since state and federal several legislative initiatives in recent years have been predicated on such terminology, a study was conducted to identify what the "prudent layperson" was likely to identify as "emergency medical conditions." After a comprehensive tabulation of symptom classifications from the diagnostic coding manual (the International Classification of Diseases, aka as ICD-9), a survey of non-medical laypersons was then conducted.

Researchers reported using analysis that included descriptive statistics, proportional calculations, and 95% confidence intervals.

Only 25 out of 87 signs and symptoms listed as such by the ICD-9 were considered "emergency medical conditions" by more than half of those surveyed who were self-defined as prudent laypersons. Most often listed as emergencies by them were loss of consciousness,
seizure, no recognition of one side of the body, paralysis, shock, gangrene, coughing blood, trouble breathing, chest pain, and choking. Pain (except renal colic or chest pain) was not considered an emergency; nor were signs and symptoms specifically related to gynecologic disorders.

Researchers concluded that "use of the prudent layperson standard for reimbursable emergency health services may not reflect the actual scope of symptoms necessitating emergency care."


Possible Cure for Diabetes Begins Safety Trials

Having successfully "cured" diabetes in lab animals, human trials have begun with INGAP (neogenesis-associated protein) peptide---a chemical messenger capable of triggering ransformation of pancreatic tissue into islet cells.

The discovery of INGAP began accidentally. Working to develop a laboratory model of pancreas disease, Rosenberg and Vinik wrapped an animal pancreas in cellophane. To their surprise, the isolated pancreas began to grow new islet cells. Further research showed that this happened because the pancreas was making INGAP. Later studies showed that only a small portion of INGAP -- INGAP peptide -- was needed to stimulate growth of new islet cells. Eventually, the researchers discovered the INGAP gene and learned how to make large quantities of the INGAP peptide.
Apparently, the pancreas has cells within itself with stem cell-like properties; if given the right stimulus, they can transform into beta or islet cells capable of manufacturing insulin. Even single doses of INGAP peptide have cuased increased production of insulin and a lowering of blood sugar.
The initial human study will test the safety of INGAP peptide. Initially, 62 patients with type 1 or type 2 diabetes will receive increasing doses at any of three medical centers: the University of Texas Health Science Center in San Antonio; the University of North Carolina in Chapel Hill; and the MedStar Research Institute in Washington, D.C.

INGAP peptide was invented by Lawrence Rosenberg, MD, PhD, of Canada's McGill University and Aaron I. Vinik, MD, of East Virginia Medical School, Norfolk, patented by the two universities and licensed to GMP Companies Inc., Ft. Lauderdale, Fla. An earlier licensing agreement with Eli Lilly and Company expired.

Islet cell transplantation is another alternative being explored. Tissue rejection does not seem to be a significant problem, but supply of donor tissue may be. There is a major study underway focusing on islet cell transplantation. Currently, it takes two donors to provide enough islet cells for a single transplant. It is estimated that 3,000 donor organs become available each year and there are some 800,000 people with type 1 diabetes.


Audio Cassette Tape on Bioterrorism

(from the web site for American College of Physicians--American Society of Internal Medicine):

The audio recording of the Distinguished Lecture by Richard P. Wenzel, FACP on Bioterrorism is now available. Recorded at the 2000 ACP-ASIM Annual Session, the speaker, Dr. Wenzel, addresses the following three clinical questions:

What are the likely pathogens that bioweaponeers would use?
What are the likely manifestations of illness caused by these pathogens?
What are the characteristics of a biological terror agent?

To order, call toll-free 1-800 776-5454 and ask for audiotape #DL 56, Bioterrorism or order online at http://www.cmeunlimited.org/acp/dl56 (associate member $12, member $13, nonmember $14)


Factoids

Eighty-two percent of California hospital emergency rooms (ERs) lost money in 2000, says a report recently issued by the California Medical Association (CMA). CMA calculates that California ERs in
fiscal year 2000 collectively lost $325 million, up from $317 million in fiscal year 1999.


Cool Web Sites

National Library of Medicine presents… http://www.sis.nlm.nih.gov/Tox/biologicalwarfare.htm

Biological pathogens released intentionally or accidentally, or naturallyoccurring, can result in disease or death. Recent terrorist attacks in theUnited States and elsewhere have prompted widespread and justified societal concerns about the hostile use of biological agents and their
potential threats to health.

Human exposure to these agents may occur through inhalation, skin (cutaneous) exposure, or ingestion of contaminated food or water. Following exposure, physical symptoms may be delayed and sometimes confused with naturally occurring illnesses. Biological warfare agents may persist in the environment and cause problems some time after their release. The selective list of agents below fall into four major groups, three classes of microorganisms - bacteria, rickettsia, and viruses, plus bacterial toxins, which are poisonous chemicals produced by bacteria. Incubation period, duration of illness, symptoms, means of transmission, treatment, and prognosis include the following: Anthrax, Smallpox, Plague, Brucellosis, Botulism, Tularemia Q Fever, and Viral Hemorrhagic Fevers

Malpractice Reform
www.malpracticecrisis.com

Lists state by state legislative efforts at tort reform, as well as
up-to-date information and a history of malpractice concerns and reform.

Learn the difference between Hepatitis A, B, C at:
http://www.immunize.org/catg.d/p4075abc.pdf

You can see photos of vaccine-preventable diseases at:
http://www.immunize.org/catg.d/pict001.htm

A fun personality test based on color sequence selection: http://www.colorgenics.com/intro.html

 


Quotable Quotes

J Norman Mailer (1923-____) US novelist, journalist:

When considering regulations, half of what is published is probably 50% incorrect. The rest is 75% wrong.

Will Rogers (1879 - 1935) US humorist, author:

Even if you're on the right track, you'll get run over if you just sit there.

Robert Benchley US author:

Drawing on my fine command of the English language, I said nothing.


ERDOCS e-mail group (listserv)

As a Clinician providing acute and emergency medical care, you are invited to visit and participate in our new ERDOCS group at eGroups, a free, easy-to-use email group service! You have plenty of experiences to share, questions to ask, concerns and opinions to voice, suggestions, news to post, tips to offer, etc. and can do so within this framework. This is a versatile system for posting things to be sent to a group to peruse, respond to, or simply be aware of. It eliminates conventional mail delays and allows you to review and post at your leisure. (We still have the more open-ended [any visitor can observe/post] discussion group at the ACUTE CARE, INC. web site). Our goal is to give you a variety of feedback and communication tools.

The manager/moderator for this ERDOCS egroup is the webmaster for the ACUTE CARE, INC. website (http://www.acutecare.com/), Paul Hudson. You can subscribe by sending an e-mail indicating your wish to be included to Paul at mailto:paulh@acutecare.com

As this site grows, it will feature news, calendars, links to references, resources, and other useful features. We hope you will support this effort to foster ongoing communication amongst EM providers.


This e-newsletter is available through the generous unrestricted support of 
ACUTE CARE, INC. You can find out more about ACUTE CARE, INC.
by going online to http://www.acutecare.com/index.html
Archived copies of this newsletter are available at that site.

If you have questions, concerns or ideas;
Or you have trouble with the display of this e-mail, 
please send your message via e-mail to: mailto:prariedocs@aol.com
If you wish to no longer receive issues of this e-newsletter, send your
'unsubscribe" message to the same e-mail address.


Return to the ACUTE CARE home page

 

 

   
P.O. Box 4130, Des Moines, IA 50333   800.729.7813   e-mail: staff@acutecare.com